Pulmonary Perfused Blood Volume with Dual-Energy CT as Surrogate for Pulmonary Perfusion Assessed with Dynamic Multidetector CT

Published Online:https://doi.org/10.1148/radiol.12112789

This study supports the notion that CT-derived pulmonary blood volume is a suitable surrogate for CT-derived pulmonary blood flow, providing a functional measure that may lead to new insights into disease processes not achievable by simply mapping the aftermath (parenchymal destruction and airway remodeling) of the pathologic process.


To compare measurements of regional pulmonary perfused blood volume (PBV) and pulmonary blood flow (PBF) obtained with computed tomography (CT) in two pig models.

Materials and Methods

The institutional animal care and use committee approved all animal studies. CT-derived PBF and PBV were determined in four anesthetized, mechanically ventilated, supine swine by using two methods for creating pulmonary parenchymal perfusion heterogeneity. Two animals were examined after sequentially moving a pulmonary arterial balloon catheter from a distal to a central location, and two others were examined over a range of static airway pressures, which varied the extents of regional PBF. Lung sections were divided into blocks and Pearson correlation coefficients calculated to compare matching regions between the two methods.


CT-derived PBF, CT-derived PBV, and their associated coefficients of variation (CV) were closely correlated on a region-by-region basis in both the balloon occlusion (Pearson R = 0.91 and 0.73 for animals 1 and 2, respectively; Pearson R = 0.98 and 0.87 for comparison of normalized mean and CV for animals 1 and 2, respectively) and lung inflation studies (Pearson R = 0.94 and 0.74 for animals 3 and 4, respectively; Pearson R = 0.94 and 0.69 for normalized mean and CV for animals 3 and 4, respectively). When accounting for region-based effects, correlations remained highly significant at the P < .001 level.


CT-derived PBV heterogeneity is a suitable surrogate for CT-derived PBF heterogeneity.

©RSNA, 2012

Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12112789/-/DC1


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Article History

Received January 12, 2012; revision requested February 13; revision received May 25; accepted July 18; final version accepted August 14.
Published online: June 2013
Published in print: June 2013