Human Knee: In Vivo T1ρ-weighted MR Imaging at 1.5 T—Preliminary Experience

A fast spin-echo sequence weighted with a time constant that defines the magnetic relaxation of spins under the influence of a radio-frequency field (T1ρ) was used in six subjects to measure magnetic resonance (MR) relaxation times in the knee joint with a 1.5-T MR imager. A quantitative comparison of T2- and T1ρ-weighted MR images was also performed. Substantial T1ρ dispersion was demonstrated in human articular cartilage, but muscle did not demonstrate much dispersion. T1ρ-weighted images depicted a chondral lesion with 25% better signal-difference-to-noise ratios than comparable T2-weighted images. This technique may depict cartilage and muscular abnormalities.

References

  • 1 Redfield AG. Nuclear magnetic resonance saturation and rotary saturation in solids. Phys Rev 1955; 98: 1787-1809. CrossrefGoogle Scholar
  • 2 Brown RD, III, Koenig SH. 1/T1 rho and low-field 1/T1 of tissue water protons arise from magnetization transfer to macromolecular solid-state broadened lines. Magn Reson Med 1992; 28: 145-152. Crossref, MedlineGoogle Scholar
  • 3 Knispel RR, Thompson RT, Pintar MM. Dispersion of proton spin-lattice relaxation in tissues. J Magn Reson 1974; 14: 44-51. CrossrefGoogle Scholar
  • 4 Koskinen SK, Yla-Outinen H, Aho HJ, Komu ME. Magnetization transfer and spin lock MR imaging of patellar cartilage degeneration at 0.1 T. Acta Radiol 1997; 38: 1071-1075. Crossref, MedlineGoogle Scholar
  • 5 Rizi RR, Charagundla SR, Song HK, et al. Proton T1rho-dispersion imaging of rodent brain at 1.9 T. J Magn Reson Imaging 1998; 8: 1090-1096. Crossref, MedlineGoogle Scholar
  • 6 Duvvuri U, Reddy R, Patel SD, Kaufman JH, Kneeland JB, Leigh JS. T1rho-relaxation in articular cartilage: effects of enzymatic degradation. Magn Reson Med 1997; 38: 863-867. Crossref, MedlineGoogle Scholar
  • 7 Mlynarik V, Trattnig S, Huber M, Zembsch A, Imhof H. The role of relaxation times in monitoring proteoglycan depletion in articular cartilage. J Magn Reson Imaging 1999; 10: 497-502. Crossref, MedlineGoogle Scholar
  • 8 Sepponen RE, Pohjonen JA, Sipponen JT, Tanttu JI. A method for T1 rho imaging. J Comput Asst Tomogr 1985; 9: 1007- 1011. Crossref, MedlineGoogle Scholar
  • 9 Rommel E, Kimmich R, Korperich H, Kunze C, Gersonde K. T1 rho dispersion imaging and localized T1 rho dispersion relaxometry: application in vivo to mouse adenocarcinoma. Magn Reson Med 1992; 24: 149-157. Crossref, MedlineGoogle Scholar
  • 10 Markkola AT, Aronen HJ, Ramadan UA, Halavaara JT, Tanttu JI, Sepponen RE. Determination of T1rho values for head and neck tissues at 0.1 T: a comparison to T1 and T2 relaxation times. Magn Reson Imaging 1998; 16: 377-383. Crossref, MedlineGoogle Scholar
  • 11 Halavaara JT, Sepponen RE, Lamminen AE, Vehmas T, Bondestam S. Spin lock and magnetization transfer MR imaging of local liver lesions. Magn Reson Imaging 1998; 16: 359-364[Erratum: Magn Reson Imaging 1998; 16:1146.]. Crossref, MedlineGoogle Scholar
  • 12 Aronen HJ, Ramadan UA, Peltonen TK, et al. 3D spin-lock imaging of human gliomas. Magn Reson Imaging 1999; 17: 1001-1010. Crossref, MedlineGoogle Scholar
  • 13 Melki PS, Mulkern RV, Panych LP, Jolesz FA. Comparing the FAISE method with conventional dual-echo sequences. J Magn Reson Imaging 1991; 1: 319-326. Crossref, MedlineGoogle Scholar
  • 14 McCauley TR, Kier R, Lynch KJ, Jokl P. Chondromalacia patellae: diagnosis with MR imaging. AJR Am J Roentgenol 1992; 158: 101-105. Crossref, MedlineGoogle Scholar
  • 15 Yao L, Shantanu S, Seeger L. MR imaging of joints: analytic optimization of GRE techniques at 1.5 T. AJR Am J Roentgenol 1992; 158: 339-345. Crossref, MedlineGoogle Scholar
  • 16 Jones GP. Spin-lattice relaxation in the rotating frame: weak collision case. Phys Rev 1965; 148: 332-335. Google Scholar
  • 17 Santyr GE, Fairbanks EJ, Kelcz F, Sorenson JA. Off-resonance spin locking for MR imaging. Magn Reson Med 1994; 32: 43-51. Crossref, MedlineGoogle Scholar
  • 18 Cornell BA, Pope JM. A pulsed NMR study of nuclear spin-lattice relaxation in the off-resonance rotating frame. J Magn Reson 1974; 16: 172-181. Google Scholar
  • 19 Nugent A, Johnson G. Microscopic susceptibility variation and T1ρ (abstr). In: Proceedings of the Eighth Meeting of the International Society for Magnetic Resonance in Medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, 2000; 1: 512. Google Scholar
  • 20 Meiboom S. Nuclear magnetic resonance study of the proton transfer in water. J Chem Phys 1965; 34: 375-388. Google Scholar
  • 21 Charagundla SR. Indirect 17O detection with proton magnetic resonance imaging. Thesis Philadelphia: University of Pennsylvania, 2000. Google Scholar
  • 22 Maroudas A, Ziv I, Weisman N, Venn M. Studies of hydration and swelling pressure in normal and osteoarthritic cartilage. Biorheology 1985; 22: 159-169. Crossref, MedlineGoogle Scholar
  • 23 Brocklehurst R, Bayliss MT, Maroudas A, et al. The composition of normal and osteoarthritic articular cartilage from human knee joints: with special reference to unicompartmental replacement and osteotomy of the knee. J Bone Joint Surg Am 1984; 66: 95-106. Crossref, MedlineGoogle Scholar
  • 24 Lamminen A, Tanttu J, Sepponen R, Pihko H, Korhola O. T1 rho dispersion imaging of diseased muscle tissue. Br J Radiol 1993; 66: 783-787. Crossref, MedlineGoogle Scholar
  • 25 Virta A, Komu M, Lundbom N, et al. Low field T1rho imaging of myositis. Magn Reson Imaging 1998; 16: 385-391. Crossref, MedlineGoogle Scholar

Article History

Published in print: Sept 2001