Fiber Tract–based Atlas of Human White Matter Anatomy

Two- and three-dimensional (3D) white matter atlases were created on the basis of high-spatial-resolution diffusion tensor magnetic resonance (MR) imaging and 3D tract reconstruction. The 3D trajectories of 17 prominent white matter tracts could be reconstructed and depicted. Tracts were superimposed on coregistered anatomic MR images to parcel the white matter. These parcellation maps were then compared with coregistered diffusion tensor imaging color maps to assign visible structures. The results showed (a) which anatomic structures can be identified on diffusion tensor images and (b) where these anatomic units are located at each section level and orientation. The atlas may prove useful for educational and clinical purposes.

© RSNA, 2003


  • 1 Basser PJ, Mattiello J, Le Bihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994; 66:259-267. Crossref, MedlineGoogle Scholar
  • 2 Beaulieu C. The basis of anisotropic water diffusion in the nervous system: a technical review. NMR Biomed 2002; 15:435-455. Crossref, MedlineGoogle Scholar
  • 3 Moseley ME, Cohen Y, Kucharczyk J, et al. Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 1990; 176:439-445. LinkGoogle Scholar
  • 4 Pierpaoli C, Jezzard P, Basser PJ, et al. Diffusion tensor MR imaging of human brain. Radiology 1996; 201:637-648. LinkGoogle Scholar
  • 5 Makris N, Worth AJ, Sorensen AG, et al. Morphometry of in vivo human white matter association pathways with diffusion weighted magnetic resonance imaging. Ann Neurol 1997; 42:951-962. Crossref, MedlineGoogle Scholar
  • 6 Beaulieu C, Allen PS. Determinants of anisotropic water diffusion in nerves. Magn Reson Med 1994; 31:394-400. Crossref, MedlineGoogle Scholar
  • 7 Henkelman R, Stanisz G, Kim J, Bronskill M. Anisotropy of NMR properties of tissues. Magn Reson Med 1994; 32:592-601. Crossref, MedlineGoogle Scholar
  • 8 Mori S, Crain BJ, Chacko VP, van Zijl PCM. Three dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999; 45:265-269. Crossref, MedlineGoogle Scholar
  • 9 Conturo TE, Lori NF, Cull TS, et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A 1999; 96:10422-10427. Crossref, MedlineGoogle Scholar
  • 10 Basser PJ, Pajevic S, Pierpaoli C, et al. In vitro fiber tractography using DT-MRI data. Magn Reson Med 2000; 44:625-632. Crossref, MedlineGoogle Scholar
  • 11 Poupon C, Clark CA, Frouin V, et al. Regularization of diffusion-based direction maps for the tracking of brain white matter fascicules. Neuroimage 2000; 12:184-195. Crossref, MedlineGoogle Scholar
  • 12 Jones DK, Simmons A, Williams SC, Horsfield MA. Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI. Magn Reson Med 1999; 42:37-41. Crossref, MedlineGoogle Scholar
  • 13 Pajevic S, Pierpaoli C. Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magn Reson Med 1999; 42:526-540. Crossref, MedlineGoogle Scholar
  • 14 Inglis BA, Neubauer D, Yang L, et al. Diffusion tensor MR imaging and comparative histology of glioma engrafted in the rat spinal cord. AJNR Am J Neuroradiol 1999; 20:713-716. MedlineGoogle Scholar
  • 15 Huppi P, Maier S, Peled S, et al. Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr Res 1998; 44:584-590. Crossref, MedlineGoogle Scholar
  • 16 Pierpaoli C, Barnett A, Pajevic S, et al. Water diffusion changes in wallerian degeneration and their dependence on white matter architecture. Neuroimage 2001; 13:1174-1185. Crossref, MedlineGoogle Scholar
  • 17 Albayram S, Melhem ER, Mori S, et al. Holoprosencephaly in children: diffusion tensor MR imaging of white matter tracts of the brainstem—initial experience. Radiology 2002; 223:645-651. LinkGoogle Scholar
  • 18 Mori S, Fredericksen K, van Zijl PC, et al. Brain white matter anatomy of tumor patients using diffusion tensor imaging. Ann Neurol 2002; 51:377-380. Crossref, MedlineGoogle Scholar
  • 19 Hoon AH, Jr, Lawrie WT, Jr, Melhem ER, et al. Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways. Neurology 2002; 59:752-756. Crossref, MedlineGoogle Scholar
  • 20 Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med 1999; 42:952-962. Crossref, MedlineGoogle Scholar
  • 21 Bammer R, Auer M, Keeling SL, et al. Diffusion tensor imaging using single-shot SENSE-EPI. Magn Reson Med 2002; 48:128-136. Crossref, MedlineGoogle Scholar
  • 22 Jones DK, Horsfield MA, Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 1999; 42:515-525. Crossref, MedlineGoogle Scholar
  • 23 Xue R, van Zijl PCM, Crain BJ, et al. In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging. Magn Reson Med 1999; 42:1123-1127. Crossref, MedlineGoogle Scholar
  • 24 Mori S, Van Zijl PC. Fiber tracking: principles and strategies—a technical review. NMR Biomed 2002; 15:468-480. Crossref, MedlineGoogle Scholar
  • 25 Stieltjes B, Kaufmann WE, van Zijl PCM, et al. Diffusion tensor imaging and axonal tracking in the human brainstem. Neuroimage 2001; 14:723-735. Crossref, MedlineGoogle Scholar
  • 26 Mori S, Kaufmann WE, Davatzikos C, et al. Imaging cortical association tracts in human brain. Magn Reson Med 2002; 47:215-223. Crossref, MedlineGoogle Scholar
  • 27 Catani M, Howard RJ, Pajevic S, Jones DK. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002; 17:77-94. Crossref, MedlineGoogle Scholar
  • 28 Zhang S, Laidlaw D. Elucidating neural structure in diffusion tensor MRI volumes using streamtubes and streamsurfaces (abstr) In: Proceedings of the Ninth Meeting of the International Society for Magnetic Resonance in Medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, 2001; 505. Google Scholar
  • 29 Carpenter M. Human neuroanatomy Baltimore, Md: Williams & Wilkins, 1976. Google Scholar
  • 30 Nieuwenhuys R, Voogd J, van Huijzen C. The human central nervous system Berlin, Germany: Springer-Verlag, 1983. Google Scholar
  • 31 Williams TH, Gluhbegovic N, Jew JY. The human brain: dissections of the real brain Virtual Hospital, University of Iowa. Available at: Accessed October 15, 2003. Google Scholar
  • 32 Nolte J, Angevine JB, Jr. The human brain in photographs and diagrams St Louis, Mo: Mosby, 2000. Google Scholar
  • 33 Kahle W, Leonhardt H, Platzer Taschenatlas der anatomie fur studium and praxis in 3 banden Stuttgart, Germany: Thieme, 1986. Google Scholar
  • 34 Mori S, Kaufmann WK, Pearlson GD, et al. In vivo visualization of human neural pathways by MRI. Ann Neurol 2000; 47:412-414. Crossref, MedlineGoogle Scholar
  • 35 Wiegell MR, Larsson H, Wedeen V. Diffusion tensor MRI of the thalamus: differentiation of nuclei by their projections (abstr) In: Proceedings of the Seventh Meeting of the International Society for Magnetic Resonance in Medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, 1999; 934. Google Scholar
  • 36 Wedeen V, Reese TG, Tuch DS, et al. Mapping fiber orientation spectra in cerebral white matter with Fourier-transform diffusion MRI (abstr) In: Proceedings of the Eighth Meeting of the International Society for Magnetic Resonance in Medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, 2000; 82. Google Scholar

Article History

Published in print: Jan 2004