Multi–Detector Row CT of Left Ventricular Function with Dedicated Analysis Software versus MR Imaging: Initial Experience

PURPOSE: To determine left ventricular (LV) volumetric and functional parameters from retrospectively electrocardiographically gated multi–detector row computed tomography (CT) by using semiautomated analysis software and to correlate results with those of magnetic resonance (MR) imaging.

MATERIALS AND METHODS: In 30 patients (mean age, 59.2 years ± 7.1 [SD]) known to have or suspected of having coronary artery disease, four-channel multi–detector row CT was performed with standard technique, and diastolic and systolic image reconstructions were generated. With commercially available analysis software capable of semiautomated contour detection, end diastolic and end systolic LV volumes were determined from short-axis secondary CT reformations. Steady-state free-precession cine MR images were acquired in short-axis orientation within 48 hours and analyzed by using dedicated software. Bland-Altman analysis was performed to calculate limits of agreement and systematic errors between CT and MR imaging.

RESULTS: Mean end diastolic (138.8 mL ± 31.9) and end systolic (53.9 mL ± 21.2) LV volumes as determined with CT correlated well with MR imaging measurements (142.0 mL ± 32.5 [r = 0.93] and 54.9 mL ± 22.8 [r = 0.94], respectively [P < .001]). LV ejection fraction (61.6% ± 10.6 for CT vs 62.3% ± 10.1 for MR imaging; r = 0.89) and stroke volume (84.6 mL ± 20.9 for CT vs 86.9 mL ± 21.5 for MR imaging; r = 0.88) also showed good correlation (P < .001). Bland-Altman analysis showed acceptable limits of agreement (±9.8% for ejection fraction) without systematic errors.

CONCLUSION: In selected patients, semiautomated analysis software enables LV volumetric and functional analysis based on multi–detector row CT data sets, the results of which correlate well with MR imaging findings.

© RSNA, 2003


  • 1 Ohnesorge B, Flohr T, Becker C, et al. Cardiac imaging by means of electrocardiographically gated multisection spiral CT: initial experience. Radiology 2000; 217:564-571. LinkGoogle Scholar
  • 2 Flohr T, Ohnesorge B. Heart rate adaptive optimization of spatial and temporal resolution for electrocardiogram-gated multislice spiral CT of the heart. J Comput Assist Tomogr 2001; 25:907-923. Crossref, MedlineGoogle Scholar
  • 3 Achenbach S, Ulzheimer S, Baum U, et al. Noninvasive coronary angiography by retrospectively ECG-gated multislice spiral CT. Circulation 2000; 102:2823-2828. Crossref, MedlineGoogle Scholar
  • 4 Nieman K, Oudkerk M, Rensing BJ, et al. Coronary angiography with multi-slice computed tomography. Lancet 2001; 357:599-603. Crossref, MedlineGoogle Scholar
  • 5 Juergens KU, Grude M, Fallenberg EM, et al. Using ECG-gated multidetector CT to evaluate global left ventricular myocardial function in patients with coronary artery disease. AJR Am J Roentgenol 2002; 179:1545-1550. Crossref, MedlineGoogle Scholar
  • 6 Wintersperger BJ, Hundt W, Knez A, et al. Left ventricular systolic function assessed by ECG gated multirow-detector spiral computed tomography (multi–detector row CT): comparison to ventriculography. Eur Radiol 2002; 12:S192. MedlineGoogle Scholar
  • 7 Dirksen MS, Bax JJ, de Roos A, et al. Usefulness of dynamic multislice computed tomography of left ventricular function in unstable angina pectoris and comparison with echocardiography. Am J Cardiol 2002; 90:1157-1160. Crossref, MedlineGoogle Scholar
  • 8 Halliburton S, Petersilka M, Schvartzman P, Obuchowski N, White R. Validation of left ventricular volume and ejection fraction measurement with multi-slice computed tomography: comparison to cine magnetic resonance imaging (abstr). Radiology 2001; 221(P):452. Google Scholar
  • 9 Juergens KU, Fischbach R, Grude M, et al. Evaluation of left ventricular myocardial function by retrospectively ECG-gated multislice spiral CT in comparison to cine magnetic resonance imaging. Eur Radiol 2002; 12:S191. Google Scholar
  • 10 Miller S, Simonetti OP, Carr J, Kramer U, Finn JP. MR imaging of the heart with cine true fast imaging with steady-state precession: influence of spatial and temporal resolutions on the left ventricular functional parameters. Radiology 2002; 223:263-269. LinkGoogle Scholar
  • 11 Thiele H, Paetsch I, Schnackenburg B, et al. Improved accuracy of quantitative assessment of left ventricular volume and ejection fraction by geometric models with steady-state-free precession. J Cardiovasc Magn Reson 2002; 4:327-339. Crossref, MedlineGoogle Scholar
  • 12 Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-310. Crossref, MedlineGoogle Scholar
  • 13 Pattynama PMT, Lamb HJ, van der Velde EA, van der Wall EE, de Roos A. Left ventricular measurements with cine and spin-echo MR imaging: a study of reproducibility with variance component analysis. Radiology 1993; 187:261-268. LinkGoogle Scholar
  • 14 Cottin Y, Touzery C, Guy F, et al. MR imaging of the heart in patients after myocardial infarction: effect of increasing intersection gap on measurements of left ventricular volume, ejection fraction, and wall thickness. Radiology 1999; 213:513-520. LinkGoogle Scholar
  • 15 Waiter GD, McKiddie FI, Redpath TW, Semple SIK, Trent RJ. Determination of normal regional left ventricular function from cine-MR images using a semi-automated edge detection method. Magn Reson Imaging 1999; 17:99-107. Crossref, MedlineGoogle Scholar
  • 16 Kivelitz DE, Enzweiler CNH, Wiese TH, et al. Determination of left ventricular function parameters and myocardial mass: comparison of MRI and EBT. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 2000; 172:244-250. [German]. CrossrefGoogle Scholar
  • 17 Boese JM, Bahner ML, Albers J, Flohr TG. An improved algorithm for multi-slice cardiac CT with high temporal resolution (abstr). Radiology 2001; 221(P):457. Google Scholar
  • 18 Halliburton SS, Boese JM, Flohr TG, Lieber ML, Kuzmiak SA, White RD. Improved volumetric analysis of left ventricle using cardiac multi-slice computed tomography (MSCT) with high temporal resolution image reconstruction (abstr). Radiology 2002; 252(P):389. Google Scholar

Article History

Published in print: Feb 2004