Insights into CT-derived Coronary Fractional Flow Reserve and Coronary Artery Calcification

Published Online:
Free first page


  • 1. Knuuti J, Wijns W, Saraste A, et al; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 2020;41(3):407–477. Crossref, MedlineGoogle Scholar
  • 2. Gulati M, Levy PD, Mukherjee D, et al; Writing Committee Members. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 2021;78(22):e187–e285. Crossref, MedlineGoogle Scholar
  • 3. Fearon WF, Nishi T, De Bruyne B, et al; FAME 2 Trial Investigators. Clinical outcomes and cost-effectiveness of fractional flow reserve-guided percutaneous coronary intervention in patients with stable coronary artery disease: three-year follow-up of the FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation). Circulation 2018;137(5):480–487. Crossref, MedlineGoogle Scholar
  • 4. Zhuang B, Wang S, Zhao S, Lu M. Computed tomography angiography-derived fractional flow reserve (CT-FFR) for the detection of myocardial ischemia with invasive fractional flow reserve as reference: systematic review and meta-analysis. Eur Radiol 2020;30(2):712–725. Crossref, MedlineGoogle Scholar
  • 5. Madsen KT, Nørgaard BL, Øvrehus KA, et al. Prognostic Value of Coronary CT Angiography–derived Fractional Flow Reserve on 3-year Outcomes in Patients with Stable Angina. Radiology 2023;308(3):e230524. Google Scholar
  • 6. Nørgaard BL, Leipsic J, Gaur S, et al; NXT Trial Study Group. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 2014;63(12):1145–1155. Crossref, MedlineGoogle Scholar
  • 7. Iwata K, Ogasawara K. Assessment of the Efficiency of Non-Invasive Diagnostic Imaging Modalities for Detecting Myocardial Ischemia in Patients Suspected of Having Stable Angina. Healthcare (Basel) 2022;11(1):23. Crossref, MedlineGoogle Scholar
  • 8. Dewey M, Siebes M, Kachelrieß M, et al; Quantitative Cardiac Imaging Study Group. Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia. Nat Rev Cardiol 2020;17(7):427–450. Crossref, MedlineGoogle Scholar

Article History

Received: Aug 15 2023
Revision requested: Aug 17 2023
Revision received: Aug 17 2023
Accepted: Aug 18 2023
Published online: Sept 12 2023