Intravenous Contrast Material Administration at Helical 16–Detector Row CT Coronary Angiography: Effect of Iodine Concentration on Vascular Attenuation

The institutional review board approved this study, and all patients gave written informed consent. One hundred twenty-five patients scheduled to undergo retrospectively electrocardiographically gated 16–detector row computed tomographic coronary angiography were prospectively randomized into the following five groups with respect to the intravenous administration of a 140-mL bolus of contrast material at 4 mL/sec: group 1 (iohexol [300 mg of iodine per milliliter]), group 2 (iodixanol [320 mg I/mL]), group 3 (iohexol [350 mg I/mL]), group 4 (iomeprol [350 mg I/mL]), and group 5 (iomeprol [400 mg I/mL]). Attenuation was measured in the descending aorta and coronary arteries. One-way analysis of variance was used to compare groups. Mean attenuation values in the descending aorta were significantly (P < .05) lower in group 1 and higher in group 5 compared with the mean values in the other three groups. The same pattern was observed in the coronary arteries. Contrast materials with higher iodine concentrations yield significantly higher attenuation in the descending aorta and coronary arteries.

© RSNA, 2005


  • 1 Nieman K, Cademartiri F, Lemos PA, Raaijmakers R, Pattynama PM, de Feyter PJ. Reliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography. Circulation 2002; 106:2051–2054. Crossref, MedlineGoogle Scholar
  • 2 Ropers D, Baum U, Pohle K, et al. Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction. Circulation 2003; 107:664–666. Crossref, MedlineGoogle Scholar
  • 3 Heuschmid M, Kuttner A, Flohr T, et al. Visualization of coronary arteries in CT as assessed by a new 16 slice technology and reduced gantry rotation time: first experiences. Rofo 2002; 174:721–724. Crossref, MedlineGoogle Scholar
  • 4 Flohr T, Stierstorfer K, Bruder H, Simon J, Schaller S. New technical developments in multislice CT. I. Approaching isotropic resolution with sub-millimeter 16-slice scanning. Rofo 2002; 174:839–845. Google Scholar
  • 5 Flohr T, Bruder H, Stierstorfer K, Simon J, Schaller S, Ohnesorge B. New technical developments in multislice CT. II. Sub-millimeter 16-slice scanning and increased gantry rotation speed for cardiac imaging. Rofo 2002; 174:1022–1027. Google Scholar
  • 6 Cademartiri F, van der Lugt A, Luccichenti G, Pavone P, Krestin GP. Parameters affecting bolus geometry in CTA: a review. J Comput Assist Tomogr 2002; 26:598–607. Crossref, MedlineGoogle Scholar
  • 7 Bae KT, Heiken JP, Brink JA. Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate—pharmacokinetic analysis and experimental porcine model. Radiology 1998; 206:455–464. LinkGoogle Scholar
  • 8 Fleischmann D, Rubin GD, Bankier AA, Hittmair K. Improved uniformity of aortic enhancement with customized contrast medium injection protocols at CT angiography. Radiology 2000; 214:363–371. LinkGoogle Scholar
  • 9 Cademartiri F, Nieman K, van der Lugt A, et al. Intravenous contrast material administration at 16-detector row helical CT coronary angiography: test bolus versus bolus-tracking technique. Radiology 2004; 233:817–823. LinkGoogle Scholar
  • 10 Becker CR, Hong C, Knez A, et al. Optimal contrast application for cardiac 4-detector-row computed tomography. Invest Radiol 2003; 38:690–694. Crossref, MedlineGoogle Scholar
  • 11 Han JK, Kim AY, Lee KY, et al. Factors influencing vascular and hepatic enhancement at CT: experimental study on injection protocol using a canine model. J Comput Assist Tomogr 2000; 24:400–406. Crossref, MedlineGoogle Scholar
  • 12 Bluemke DA, Fishman EK, Anderson JH. Effect of contrast concentration on abdominal enhancement in the rabbit: spiral computed tomography evaluation. Acad Radiol 1995; 2:226–231. Crossref, MedlineGoogle Scholar
  • 13 Fleischmann D. Use of high concentration contrast media: principles and rationale—vascular district. Eur J Radiol 2003; 45(suppl 1):S88–S93. Crossref, MedlineGoogle Scholar
  • 14 Brink JA. Use of high concentration contrast media (HCCM): principles and rationale—body CT. Eur J Radiol 2003; 45(suppl 1):S53–S58. Crossref, MedlineGoogle Scholar
  • 15 Brink JA. Contrast optimization and scan timing for single and multidetector-row computed tomography. J Comput Assist Tomogr 2003; 27(suppl 1):S3–S8. Crossref, MedlineGoogle Scholar
  • 16 Merkle EM, Boll DT, Fenchel S. Helical computed tomography of the pancreas: potential impact of higher concentrated contrast agents and multidetector technology. J Comput Assist Tomogr 2003; 27(suppl 1):S17–S22. Crossref, MedlineGoogle Scholar

Article History

Published in print: Aug 2005