High-Spatial-Resolution Multistation MR Angiography with Parallel Imaging and Blood Pool Contrast Agent: Initial Experience

The purpose of this study was to prospectively evaluate the diagnostic accuracy of reader detection of 75% or greater stenosis at high-spatial-resolution multistation magnetic resonance (MR) angiography performed with matrix coils and a blood pool contrast agent. Ten healthy volunteers and 10 patients were examined. All participants provided informed consent to participate in this institutional review board–approved study. For contrast agent–enhanced multistation MR angiography, an albumin-binding gadolinium chelate, gadofosveset trisodium, was used. Imaging was performed during the first-pass and steady-state phases of the contrast agent. Vessel conspicuity on the first-pass MR angiograms obtained in both volunteers and patients was rated as excellent for 93% of vessels. At steady-state imaging, vessel conspicuity was rated as excellent or good for 89% of vessels. Gadofosveset trisodium–enhanced MR angiography yielded sensitivities of 100% and 97% and specificities of 96% and 97% for detection of significant disease in the carotid and lower extremity arteries, respectively.

Supplemental material: radiology.rsnajnls.org/cgi/content/full/2413060053/DC1 radiology.rsnajnls.org/cgi/content/full/2413060053/DC2

© RSNA, 2006

References

  • 1 Buskens E, Nederkoorn PJ, Buijs-Van Der Woude T, et al. Imaging of carotid arteries in symptomatic patients: cost-effectiveness of diagnostic strategies. Radiology 2004; 233: 101–112.
  • 2 Schoenberg SO, Rieger J, Weber CH, et al. High-spatial-resolution MR angiography of renal arteries with integrated parallel acquisitions: comparison with digital subtraction angiography and US. Radiology 2005;235:687–698.
  • 3 Meissner OA, Rieger J, Weber C, et al. Critical limb ischemia: hybrid MR angiography compared with DSA. Radiology 2005;235:308–318.
  • 4 Ruehm SG, Goyen M, Barkhausen J, et al. Rapid magnetic resonance angiography for detection of atherosclerosis. Lancet 2001;357:1086–1091.
  • 5 Herborn CU, Goyen M, Quick HH, et al. Whole-body 3D MR angiography of patients with peripheral arterial occlusive disease. AJR Am J Roentgenol 2004;182:1427–1434.
  • 6 Ruehm SG, Goyen M, Quick HH, et al. Whole-body MR angiography on a rolling table platform (AngioSURF) [in German]. Rofo 2000;172:670–674.
  • 7 Kramer H, Schoenberg SO, Nikolaou K, et al. Cardiovascular screening with parallel imaging techniques and a whole-body MR imager. Radiology 2005;236:300–310.
  • 8 Vogt FM, Ajaj W, Hunold P, et al. Venous compression at high-spatial-resolution three-dimensional MR angiography of peripheral arteries. Radiology 2004;233:913–920.
  • 9 Bilecen D, Jager KA, Aschwanden M, Heidecker HG, Schulte AC, Bongartz G. Cuff-compression of the proximal calf to reduce venous contamination in contrast-enhanced stepping-table magnetic resonance angiography. Acta Radiol 2004;45:510–515.
  • 10 Vasbinder GB, Nelemans PJ, Kessels AG, Kroon AA, de Leeuw PW, van Engelshoven JM. Diagnostic tests for renal artery stenosis in patients suspected of having renovascular hypertension: a meta-analysis. Ann Intern Med 2001;135:401–411.
  • 11 Vasbinder GB, Nelemans PJ, Kessels AG, et al. Accuracy of computed tomographic angiography and magnetic resonance angiography for diagnosing renal artery stenosis. Ann Intern Med 2004;141:674–682.
  • 12 Perreault P, Edelman MA, Baum RA, et al. MR angiography with gadofosveset trisodium for peripheral vascular disease: phase II trial. Radiology 2003;229:811–820.
  • 13 Lauffer RB, Parmelee DJ, Dunham SU, et al. MS-325: albumin-targeted contrast agent for MR angiography. Radiology 1998;207:529–538.
  • 14 Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005;40:715–724.
  • 15 Griswold MA, Jakob PM, Heidemann RM, et al. Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 2002;47:1202–1210.
  • 16 Mallouhi A, Schocke M, Judmaier W, et al. 3D MR angiography of renal arteries: comparison of volume rendering and maximum intensity projection algorithms. Radiology 2002;223:509–516.
  • 17 Goyen M, Edelman M, Perreault P, et al. MR angiography of aortoiliac occlusive disease: a phase III study of the safety and effectiveness of the blood-pool contrast agent MS-325. Radiology 2005;236:825–833.
  • 18 Rapp JH, Wolff SD, Quinn SF, et al. Aortoiliac occlusive disease in patients with known or suspected peripheral vascular disease: safety and efficacy of gadofosveset-enhanced MR angiography—multicenter comparative phase III study. Radiology 2005;236:71–78.

Article History

Published in print: 2006