Pancreatic Perfusion: Noninvasive Quantitative Assessment with Dynamic Contrast-enhanced MR Imaging without and with Secretin Stimulation in Healthy Volunteers—Initial Results
Abstract
Purpose: To prospectively quantify pancreatic regional perfusion with dynamic contrast material–enhanced magnetic resonance (MR) imaging by using a one-compartment model and to assess perfusion changes during secretin stimulation in healthy volunteers.
Materials and Methods: The study had institutional review board approval, and written informed consent was obtained. Ten healthy volunteers (five men, five women; mean age, 24.7 years ± 1.9 [standard deviation]; range, 22–29 years) underwent MR imaging pancreatic perfusion studies performed twice without secretin and twice during secretin stimulation. Dynamic contrast-enhanced MR imaging consisted of saturation-recovery T1-weighted turbo-field-echo imaging with peripheral pulse triggering and respiratory tracking. A dose of 0.05 mmol gadodiamide per kilogram of body weight was injected at a rate of 3.5 mL/sec. Regional perfusion parameters were fitted with a one-compartment model. The analysis of variance test for repeated measurements was used to assess differences in pancreatic perfusion without and that with secretin administration.
Results: Significant differences in perfusion parameters between the three pancreatic regions were observed (P < .05). During secretin stimulation, a significant difference was observed only between the body and the tail of the pancreas (P = .02). A significant increase (P = .003) in pancreatic perfusion was observed after secretin administration. Mean pancreatic perfusion was 184 mL/min/100 g of tissue ± 71, 207 mL/min/100 g ± 77, and 230 mL/min/100 g ± 87 without secretin and 342 mL/min/100 g ± 154, 338 mL/min/100 g ± 156, and 373 mL/min/100 g ± 176 after secretin stimulation in the head, body, and tail of the pancreas, respectively. Intraindividual variability was 21% without secretin stimulation and 46% with secretin stimulation.
Conclusion: Dynamic contrast-enhanced MR imaging enables noninvasive quantification of regional pancreatic perfusion in resting conditions and demonstrates the increase in pancreatic perfusion during secretin stimulation in healthy subjects.
© RSNA, 2008
References
- 1
Kubo S - 2
D'Onofrio M - 3
Sofuni A - 4
Miles KA - 5
Bize PE - 6
McMenamin DA - 7
Carmona-Sanchez R - 8
Hwang TL - 9
Tajima Y - 10
Coenegrachts K - 11
Tofts PS - 12
Materne R - 13
Pruessmann KP - 14
In den Kleef JJ - 15
Brix G - 16
Guyton AC - 17
Holton P - 18
Eichelter P - 19
Delaney JP - 20
Chung RS - 21
Widdison AL - 22
Dreiling DA - 23
Aune S - 24
Annet L - 25
Peeters F
