Technical Developments

Regional Blood Flow, Capillary Permeability, and Compartmental Volumes: Measurement with Dynamic CT—Initial Experience

Abstract

Sequential computed tomographic scanning was performed in patients with neck tumors after contrast material administration. For data analysis, a pharmacokinetic two-compartment model was employed that takes into account both capillary blood supply and bidirectional diffusion of the contrast agent across the capillary wall. This approach offers the possibility to quantitatively characterize tissue microcirculation with regional blood flow, capillary permeability, and relative compartmental volumes.

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Article History

Accepted: July 20 1998
Received: Jan 28 1998
Revision received: Mar 06 1998
Revision received: May 21 1998
Published in print: Jan 1999

Vol. 210, No. 1

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