Diagnostic Clues to Ectopic Pregnancy
Abstract
Ectopic pregnancy accounts for approximately 2% of all pregnancies and is the most common cause of pregnancy-related mortality in the first trimester. Initial evaluation consists of hormonal assays and pelvic ultrasonography (US). A history of pelvic pain along with an abnormal β human chorionic gonadotropin level should trigger an evaluation for an ectopic pregnancy. The fallopian tube is the most common location for an ectopic pregnancy. An adnexal mass that is separate from the ovary and the tubal ring sign are the most common findings of a tubal pregnancy. Other types of ectopic pregnancy include interstitial, cornual, ovarian, cervical, scar, intraabdominal, and heterotopic pregnancy. Interstitial pregnancy occurs when the gestational sac implants in the myometrial segment of the fallopian tube. Cornual pregnancy refers to the implantation of a blastocyst within the cornua of a bicornuate or septate uterus. An ovarian pregnancy occurs when an ovum is fertilized and is retained within the ovary. Cervical pregnancy results from an implantation within the endocervical canal. In a scar pregnancy, implantation takes place within the scar of a prior cesarean section. In an intraabdominal pregnancy, implantation occurs within the intraperitoneal cavity. Heterotopic pregnancy occurs when an intrauterine and an extrauterine pregnancy occur simultaneously. A spectrum of intra- and extrauterine findings may be seen on US images. Although many of the US findings are nonspecific by themselves, when several of them are seen, the specificity of US in depicting an ectopic pregnancy substantially improves.
© RSNA, 2008
References
- 1 Centers for Disease Control and Prevention (CDC). Ectopic pregnancy: United States, 1990–1992. MMWR Morb Mortal Wkly Rep 1995; 44: 46–48. Medline, Google Scholar
- 2
, Potter B. Diagnosis and management of ectopic pregnancy. Am Fam Physician2005; 72: 1707–1714. Medline, Google ScholarLozeau AM - 3
, Stovall TG, Ling FW. Nonsurgical treatment of ectopic pregnancy. N Engl J Med2000; 343: 1325–1329. Crossref, Medline, Google ScholarLipscomb GH - 4
. Endocrinology of ectopic pregnancy. Obstet Gynecol Clin North Am2004; 31: 779–794. Crossref, Medline, Google ScholarAttar E - 5
. Human chorionic gonadotropin increase in normal early pregnancy. Am J Obstet Gynecol1987; 156: 286–290. Crossref, Medline, Google ScholarDaya S - 6
, Reish RL, Wentz AC. Doubling times of human chorionic gonadotropin increase in early viable intrauterine pregnancies. Am J Obstet Gynecol1985; 152: 299–302. Crossref, Medline, Google ScholarPittaway DE - 7
, Levine D. Imaging of pelvic pain in the first trimester of pregnancy. Radiol Clin North Am2006; 44: 863–877. Crossref, Medline, Google ScholarEyvazzadeh AD - 8
, Berger P, Bidart JM, et al. Preparation and characterization of new WHO reference agents for human chorionic gonadotropin and metabolites. Clin Chem2003; 49: 144–154. Crossref, Medline, Google ScholarBirken S - 9
, Barnhart KT. Suspected ectopic pregnancy. Obstet Gynecol2006; 107: 399–413. Crossref, Medline, Google ScholarSeeber BE - 10
, Muram D, Buster JE, Arheart KL, Stovall TG, Carson SA. Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Fertil Steril1996; 66: 513–532. Crossref, Medline, Google ScholarMcCord ML - 11
, Ramanujam P, Dart L. Progesterone as a predictor of ectopic pregnancy when the ultrasound is indeterminate. Am J Emerg Med2002; 20: 575–579. Crossref, Medline, Google ScholarDart R - 12
. Ectopic pregnancy. Radiology2007; 245: 385–397. Link, Google ScholarLevine D - 13
, Van den Hof MC. SOGC clinical practice guidelines: ultrasound evaluation of first trimester pregnancy complications. Int J Gynaecol Obstet2006; 93: 77–81. Crossref, Medline, Google ScholarMorin L - 14
, Filly RA, Damato N. Sonographic diagnosis of ectopic pregnancy with endovaginal probes: what really has changed? J Ultrasound Med1993; 12: 145–151. Crossref, Medline, Google ScholarRussell SA - 15
, Hill LM. Normal early intrauterine pregnancy: sonographic development and HCG correlation. In: Patterson AS, ed. Transvaginal ultrasound. St Louis, Mo: Mosby, 1992; 64–85. Google ScholarNyberg DA - 16
, Bhatt S, Nour S. Sonographic evaluation of first-trimester bleeding. Radiol Clin North Am2004; 42: 297–314. Crossref, Medline, Google ScholarPaspulati RM - 17
, Aslam N, Zosmer N, Woelfer B, Jurkovic D. The expectant management of women with early pregnancy of unknown location. Ultrasound Obstet Gynecol1999; 14: 231–236. Crossref, Medline, Google ScholarBanerjee S - 18
, Coste J, Fernandez H, Pouly JL, Job-Spira N. Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod2002; 17: 3224–3230. Crossref, Medline, Google ScholarBouyer J - 19
, Green GE, Scoutt LM. Adnexal mass with pelvic pain. Radiol Clin North Am2004; 42: 329–348. Crossref, Medline, Google ScholarWebb EM - 20
, Levine D. Ectopic pregnancy: a review. Ultrasound Q2004; 20: 105–117. Crossref, Medline, Google ScholarDialani V - 21
, Leduc C, Gillett P, et al. Role of endovaginal sonography in the diagnosis and management of ectopic pregnancy. RadioGraphics1996; 16: 755–774. Link, Google ScholarAtri M - 22
, Lyon M. Reliability of adnexal mass mobility in distinguishing possible ectopic pregnancy from corpus luteum cysts. J Ultrasound Med2005; 24: 599–603. Crossref, Medline, Google ScholarBlaivas M - 23
, Taylor KJ, Quedens-Case C, et al. Ectopic pregnancy: evaluation with endovaginal color flow imaging. Radiology1992; 183: 407–411. Link, Google ScholarPellerito JS - 24
, Frates MC. Sonographic spectrum of the corpus luteum in early pregnancy: gray-scale, color, and pulsed Doppler appearance. J Clin Ultrasound1999; 27: 55–59. Crossref, Medline, Google ScholarDurfee SM - 25
, Ghazale H, Dogra VS. Sonographic evaluation of ectopic pregnancy. Radiol Clin North Am2007; 45: 549–560. Crossref, Medline, Google ScholarBhatt S - 26
, Rabinowitz JG. Amniotic sac development: ultrasound features of early pregnancy—the double bleb sign. Radiology1988; 166: 97–103. Link, Google ScholarYeh HC - 27
, Hammoud I, Bujold E, Gonik B, Diamond MP, Johnson SC. The role of sonographic endometrial patterns and endometrial thickness in the differential diagnosis of ectopic pregnancy. Am J Obstet Gynecol2005; 192: 1370–1375. Crossref, Medline, Google ScholarHammoud AO - 28
, Paspulati RM, Bhatt S. First trimester bleeding evaluation. Ultrasound Q2005; 21: 69–85. Medline, Google ScholarDogra V - 29
, van Dongen PW, Willemsen WN, Klapwijk CW. Ultrasound diagnosis of interstitial pregnancy. Eur J Obstet Gynecol Reprod Biol1992; 47: 164–166. Crossref, Medline, Google Scholarde Boer CN - 30
, Bates SK. Semantics and pitfalls in the diagnosis of cornual/interstitial pregnancy. Fertil Steril2006; 86: 1764.e11–e14. Crossref, Medline, Google ScholarMalinowski A - 31
, Levi CS, Dashefsky SM, Holt SC, Lindsay DJ. Interstitial line: sonographic finding in interstitial (cornual) ectopic pregnancy. Radiology1993; 189: 83–87. Link, Google ScholarAckerman TE - 32
, Tulandi T. Conservative medical and surgical management of interstitial ectopic pregnancy. Fertil Steril1999; 72: 207–215. Crossref, Medline, Google ScholarLau S - 33
, Saleh A. Surgical management of ectopic pregnancy. Clin Obstet Gynecol1999; 42: 31–38. Crossref, Medline, Google ScholarTulandi T - 34
, Monteagudo A, Matera C, Veit CR. Sonographic evolution of cornual pregnancies treated without surgery. Obstet Gynecol1992; 79: 1044–1049. Medline, Google ScholarTimor-Tritsch IE - 35
, Nomura T, Wakuda K, Ishiguro T, Yoshida Y. Combined intrauterine and ovarian pregnancy: a case report. Asia Oceania J Obstet Gynaecol1994; 20: 25–29. Medline, Google ScholarHirose M - 36
, Avantario C, Farnelli C, Papeo R, Savona A. Combined intrauterine and ovarian pregnancy after in vitro fertilization and embryo transfer: a case report. Clin Exp Obstet Gynecol2001; 28: 100–101. Medline, Google ScholarMelilli GA - 37
, Magnusson SS, Benediktsdottir K. Ovarian pregnancy and IUCD use in a defined complete population. Acta Obstet Gynecol Scand1987; 66: 607–610. Crossref, Medline, Google ScholarHerbertsson G - 38
. Zur casuistic der ovarialschwangerschaft. Arch Gynaekol1878; 13: 73. Crossref, Google ScholarSpiegelberg O - 39
, Mauger-Tinlot F, Gravier A, Verspyck E, Marpeau L. Ovarian pregnancies: reevaluation of diagnostic criteria [in French]. J Gynecol Obstet Biol Reprod (Paris)2002; 31: 741–746. Medline, Google ScholarSergent F - 40
, Tulandi T. Cervical pregnancy: the importance of early diagnosis and treatment. J Minim Invasive Gynecol2007; 14: 481–484. Crossref, Medline, Google ScholarVela G - 41
, Urdl W, Höfler H, Hönigl W, Tamussino K. Cervical pregnancy: case reports and current concepts in diagnosis and treatment. Arch Gynecol Obstet1987; 241: 63–69. Crossref, Medline, Google ScholarHofmann HM - 42
, Lin H, Hsu TY, et al. Differential diagnosis of suspected cervical pregnancy and conservative treatment with the combination of laparoscopy-assisted uterine artery ligation and hysteroscopic endocervical resection. Fertil Steril2004; 81: 1642–1649. Crossref, Medline, Google ScholarKung FT - 43
, Hacket E, Campbell S. Diagnosis and treatment of early cervical pregnancy: a review and a report of two cases treated conservatively. Ultrasound Obstet Gynecol1996; 8: 373–380. Crossref, Medline, Google ScholarJurkovic D - 44
, Smith A, Maxwell D. Caesarean scar pregnancy. BJOG2007; 114: 253–263. Crossref, Medline, Google ScholarAsh A - 45
, Bassil S, Donnez J. An ectopic pregnancy developing in a previous caesarean section scar. Fertil Steril1997; 67: 398–400. Crossref, Medline, Google ScholarGodin PA - 46
, Wang W, Tang XL, Wang Y. Cesarean scar pregnancy: a case report. Chin Med J (Engl)2004; 117: 316–317. Medline, Google ScholarLi SP - 47
, Bhatt S, Dogra VS. Abdominal pregnancy: an unusual presentation. J Ultrasound Med2008; 27: 679–681. Crossref, Medline, Google ScholarParekh VK - 48
, Schenker JG. Heterotopic pregnancy and assisted reproduction: an update. J Assist Reprod Genet1996; 13: 594–601. Crossref, Medline, Google ScholarRojansky N - 49
, Friede A, Hogue CJ. Abdominal pregnancy in the United States: frequency and maternal mortality. Obstet Gynecol1987; 69: 333–337. Medline, Google ScholarAtrash HK - 50
, Gervaise A. Ectopic pregnancy after infertility treatment: modern diagnosis and therapeutic strategy. Hum Reprod Update2004; 10: 503–513. Crossref, Medline, Google ScholarFernandez H